My Last Duchess And Porphyrias Lover Comparison - 858 Words

obert Browning, on the surface is a celebrated poet. But what was on the inside? We may have a glimpse into his mind through his poems. Specifically, his two poems My Last Duchess, and Porphyria’s Lover. These two texts share some startling similarities, and some thoughtful differences. â€Å"Social comparison is important.† (Festinger) Browning’s two poems My Last Duchess and Porphyria’s Lover follow a similar idea, and in the following text, will be compared in three main areas. The first area of discussion is who is telling the story. In My Last Duchess, the narrator is a vastly wealthy Duke, who lives in a massive house with its own art gallery. In Porphyria’s Lover however, the narrator is a man, who we are led to believe is poor. He†¦show more content†¦This made him jealous because he believed that she was smiling at other men. On the other hand, Porphyria’s Lover woodsman jealousy is more convoluted. It’s never said up front on why he was mad. But after reading deeply into the words, one can conclude that he was upset at her power, and how she was above him. This makes sense if we look at the time that both of these poems take place in, Victorian Era England. This was a time where women, despite gaining traction, had little to no right or say in the world they lived in. Having said that, both men were more than likely overly masculine, and felt weak and startled when a woman defied their silly patriarchal rules. This is what led them to end the lives of their so-called loved ones. Finally, a major contrast is what each woman does. I briefly touched on the Duchess’ actions, but not on Porphyria’s. As previously mentioned, the Duke’s wife smiled at everything, and this angered him. A quote from the text to prove this is (She had heart-and shall I say?-too soon made glad?† (980) But what is interesting about that, is that we are told this through the Duke’s words. The Duke tells us what angered him, he lets us know why she was killed. But the woodsman in Porphyria’s Lover doesn’t directly say why, unlike his wealthy counterpart. In fact the woodsman tells us why without telling us, as Mr. McGee would say. Perhaps the woodsman doesn’t know why he killed his gal pal, maybe this is why he simply tells whatShow MoreRelatedPorphyrias Lover And My Last Duchess Comparison789 Words   |  4 PagesMeaning Of Brownings Porphyrias Lover and My Last Duchess (An Analysis of Comparing and Contrasting Brownings poems called Porphyrias Lover and My Last Duchess) Robert Browning was a Victorian poet. He portrayed an understanding of gender rules in his poems. Browning’s poems are similar to a puzzle, which makes the reader have to figure out what is really being said in the poem. Browning wrote two famous dramatic monologue poems called Porphyrias Lover and My Last Duchess. His poems create aRead MoreA Comparison of Porphyria’s Lover and My Last Duchess by Robert Browning1188 Words   |  5 PagesA Comparison of Porphyria’s Lover and My Last Duchess by Robert Browning The two poems ‘Porphyria’s lover’ and ‘my last duchess’ by Robert Browning shows a dramatic monologue. Dramatic monologue is a story that is told by one person; which means you only get one point of view; in the two poems they are based on the narrator’s crisis, his feelings and his way of thinking; and you have to believe it because that is the only view your going to encounter. In dramaticRead MoreEssay on A Comparison Between My Last Duchess and Porphyrias Lover2909 Words   |  12 PagesA Comparison Between My Last Duchess and Porphyrias Lover Works Cited Missing Robert Browning was one of the greatest poets of the nineteenth century and is still considered one of the major poets of the Victorian era. He was born in 1812 and married the privately educated poet, Elizabeth Browning, in 1846. They eloped to Florence, Italy, where his wife gaveRead MoreComparison of ‘Porphyria’s Lover’ and ‘My Last Duchess’ Essay1232 Words   |  5 Pages‘Porphyria’s Lover’ and ‘My Last Duchess’ are both poems by the Victorian poet Robert Browning. In this essay I will compare these two poems to find similarities and differences. Both of these poems can be used read from different points of view and they could also be used to show how society treated women in the Nineteenth Century: as assets, possessions. Both of these poems are what are known as a dramatic monologue as well as being written in the first person. The whole poem is only one stanzaRead MoreA Comparison of the Dramatic Monologues of Porphyrias Lover and My Last Duchess by Robert Browning665 Words   |  3 PagesA Comparison of the Dramatic Monologues of Porphyrias Lover and My Last Duchess by Robert Browning Robert Browning (1812-89) was, with Alfred Lord Tennyson, one of the two most celebrated of Victorian poets. His father was a bank clerk, and Browning educated himself by reading in the family library. He published many verse dramas and dramatic monologues (poems, like My Last Duchess, in which a single character speaks to the reader), notably the collections Men and WomenRead MoreEssay about A Comparison of My Last Duchess and Porphyrias Lover1182 Words   |  5 PagesMy Last Duchess is a poem about an arrogant and extremely powerful Duke who is describing his deceased Duchess. From the word last in the title it is implied that the duke has had more than one duchess. In this poem, the Duke is extremely egotistic. He says, I choose never to stoop. The duchess would look at everyone in the world as being equal no matter what class they are. The duke however cannot do this. He is too worried about his appearance. Porphyrias Lover is a poem in whichRead MoreCompare My Last Duchess And Porphyrias Lover1098 Words   |  5 PagesLove That Kills (Comparing and Contrasting of â€Å"My Last Duchess† and â€Å"Porphyria’s Lover†) While reading the poems â€Å"My Last Duchess† and â€Å"Porphyria’s Lover† by Robert Browning, there is a large possibility that you may be left haunted by the words that were written on the paper. â€Å" This is not to say that he was blandly optimistic, as he is sometimes portrayed. He wrote fully about the world s cruelty and vice and was quite frank that he had himself had no divine revelation. Nevertheless, he resolvedRead MorePorphyrias Lover And My Last Duchess Comparison Essay1440 Words   |  6 PagesComparison between Porphyrias Lover and My Last Duchess Browning had a place with the Victorian Age, an age where adore coincided with disarray, religion, and distress. Taking care of business, Browning is a writer of affection. His works delineate the different shades of feeling, regardless of whether it is the smooth stream of perfect otherworldly love in The Last Ride Together or the complexities of brain and nature of affection in Porphyrias Lover and My Last Duchess. To draw an examinationRead More Robert Browning and the Power of the Dramatic Monologue Form1432 Words   |  6 Pagespoets, allows the writer to engage more directly with his reader by placing him in the role of listener. Robert Browning utilised the form to a famously profound effect, creating a startling aspect to his poetry. In poems such as â€Å"Porphyria’s Lover,† and â€Å"My Last Duchess,† for example, Browning induces a feeling of intimacy by presenting the reader as the ‘confidant’ to the narrator’s crimes; in â€Å"Soliloquy of the Spanish Cloister,† the reader is more a witness to the narrator’s increasing instabilityRead More Relationships Between Women and Men in Brownings Poems Essay2589 Words   |  11 PagesBrowning’s poems including: My Last Duchess, a dramatic monologue in which the Duke speaks to an imaginary listener about a painting of his last duchess. Porphyria’s Love, another dramatic monologue where Porphyria’s lover speaks to himself about his Love surrounded by anxiety for Porphyria and how he overcomes it. Meeting at Night, which dramatizes the excitement and intensity of passion, the feeling of tense anticipation as the poet travels to meet his lover. However, Parting at Morning

The Legalization Of Marijuana Legalization - 996 Words

Secondly, the monetary gain of its legalization for most has been productive to say the least. For example, Denver Colorado is on track to more than triple the marijuana tax revenue this year alone. $44 million was collected in 2014. In July 2015, 73.5 million was collected, while 19.6 million went to schools. A place such as Chicago could really use the legalization to help with the school system infrastructure issues they have. With a deficit of over 1.1 billion marijuana sales could alleviate both the conditions of schools themselves, as well as provide more funding. Funding for programs designed to give at risk youth outlets to release some of the frustrations of living in such deplorable conditions. The same monetary profit could be used to help secure safer neighborhoods and first responders to police. That would save the head to outsource services providing stabilization of important economic responsibility of the state. Another important aspect to consider when ponderi ng marijuana legalization would be whether certain liberties are being upheld. For example, freewill constitutes that the government cannot dictate the freewill of individuals who expose themselves despite the risks involved. There are several harmful things our government knows is bad for us. We are legally allowed to consume them anyway, because we take that risk personally. Why does the same not apply for marijuana? Cigarettes contains several harmful ingredients. However labelingShow MoreRelatedThe Legalization Of Marijuana Legalization Essay2566 Words   |  11 Pagescurrent prohibition on marijuana reforms has put the United States in a similar situation. Marijuana is the most widely used illicit drug in the United States. According to the National Survey on Drug Use and Health, â€Å"95 million Americans age 12 and older have tried pot at least once, and three out of every four illicit-drug users reported using marijuana within the previous 30 days† (ONDCP). The decriminalization and eventually legalization for the recreational use of marijuana will bring forth benefitsRead MoreThe Legalization Of Marijuana Legalization1061 Words   |  5 PagesThe Legalization of Cannabis in Ohio Marijuana is a controversial topic all across the United States. Recently marijuana has been voted on, legalized, and denied legalization in multiple states. There are still more states trying to fight the green fight for marijuana. The fight for legalization hasn’t been an easy one for cannabis supporters; they have been fighting tooth and nail to make it happen. One of the main concerns in the marijuana debates are whether or not marijuana is a gateway drugRead MoreThe Legalization Of Marijuana Legalization1282 Words   |  6 Pages On November 8th, 2016, the California Marijuana Legalization Initiative may be included on the ballot. The people of California will vote on whether to legalize the recreational use of cannabis for adults. The move targets at regulating the consumption of the drug and taxing it like other legalized drugs. California was the first state to legalize medical marijuana in 1996 (National Institute of Drug Abuse). The state prohibited any legal actio ns from being taken on patients and recognized caregiversRead MoreThe Legalization Of Marijuana Legalization1660 Words   |  7 PagesKyler Smith 9/15 â€Å"Marijuana Legalization† The legality of cannabis varies from country to country. Possession of cannabis is illegal in most countries and has been since the beginning of widespread cannabis prohibition in the late 1930s. However, possession of the drug in small quantities had been decriminalized in many countries and sub-national entities in several parts of the world. Furthermore, possession is legal or effectively legal in the Netherlands, Uruguay, and in the US states of ColoradoRead MoreLegalization of Marijuana1550 Words   |  7 PagesLegalization of Marijuana: Benefits and Statistics The topic of legalizing marijuana has been a topic of controversy for quite some time now not only throughout our local streets, but throughout the local and into the state government. The legalization of marijuana is such a controversial topic because some are for it and some are against it. People are for the legalization because of the great uses it has towards medicine, the money that could come from the taxation of legalized marijuana, andRead MoreLegalization of Marijuana972 Words   |  4 PagesOn January 1st the states of Colorado and Washington officially began the regulation of legal marijuana sales. Thousands of people from all over the country including tourists from Wisconsin, Ohio, Chicago, and even Georgia lined up out front of dispensaries to make a purchase. Recreational marijuana is being regulated and monitored like alcohol; you must be at least 21 years old to make a purchase. The drug, which is controversial in many states’ legislations, is currently l egal for medical useRead MoreLegalization Of Legalization For Recreational Marijuana1204 Words   |  5 Pagescalled Maryjane, Pot, Reefer, Ganga, Green and many other names, but this little plant seems to be causing a big controversy in recent decades. Can Marijuana really help us or is it a problem in the making? This question may seem simple, but in reality, it is more complex of an issue than we think. The opposing sides of legalization for recreational marijuana are so varied with many points of view to consider. Only a few of those views will be addressed in this article with simplified information to speakRead MoreThe Legalization of Marijuana628 Words   |  2 PagesThe Legalization of Marijuana Marijuana, the plant of the cannabis, has been around since the early 1900’s. Throughout history, marijuana has been used illegally, for both recreational and medical uses. Recently, marijuana has been used for medicinal purposes, like aiding HIV/AIDs patients, healing migraines and controlling nausea caused by chemotherapy. Today, there are currently 21 American states that have legalized medicinal marijuana including two states that have legalized recreational marijuanaRead MoreMarijuana Legalization1212 Words   |  5 PagesMarijuana Legalization COMP 1500 April 20th, 2009 Word Count: 807 Outline I. Introduction Thesis Statement: Although America is the land of the free you do not really have  too many  free choices you can make. Americans  should have  the right to  choose whether or not  marijuana should be legal. II. Background III. The tax benefits that can be created A. If legalized they can tax it how ever much they want B. Can be regulated IV. Drug enforcement money can be divertedRead MoreLegalization of Marijuana2735 Words   |  11 PagesLegalism and Marijuana People have been smoking marijuana for thousands of years while also using hemp for everything from fabric to make clothes and other items. Unfortunately, Harry J. Anslinger with a bit of power and enough determination decided pot was evil and addictive. The struggle continues to this day to overcome the lies about marijuana (â€Å"Marijuana (Weed) History and Facts†). There are many benefits to legalizing marijuana and the government should take advantage of it. Marijuana is even

Christine de Pizan Free Essays

Christine de Pizan: c. 1365-c. 1430 1. We will write a custom essay sample on Christine de Pizan or any similar topic only for you Order Now Christine’s life shows a glimpse into the changing worldview in numerous ways. For one, she became educated as a child and continued her education throughout her life, she also was able to support her family as a single mother on her own by working independently, and he writings were symbolically revolved around women in such a way that they rebuked the negative teachings by most scholars. 2. As a girl, Christine had an unusual life because her father, who was the Astrologer for Charles V, ensured that she would receive the best education possible. Later when she became older and was married, her husband also encouraged her to continue her studies. Unlike most women during the middle Ages, she was able to receive an education, as well as the support to do so. After the death of her husband she had to support her family on her own, she did so by writing short stories and poems, which people paid for. She was able to get herself out of debt this way. . Basically Christine is saying, that’s she never doubted God and his perfection, creation of all things good, wisdom. But what she doesn’t understand is how it is that women have been so heavily scrutinized and labeled with flaws if people of the faith truly believe that God created all things good. This is why she’s so angry and frustrated, she then goes on to say why wasn’t she made a man, since m en are all said to be so perfect. She apologizes and asks forgiveness for her negligence of his service, due to the fact that she is not a man. . Christine says it is not about gender, that does not make one lower than the other. It lies within that individual’s conduct and virtue. 5. She says that not all men’s opinions are based on reason, it can’t be assumed that becoming educating and learning the natural sciences can be bad for mores. Men also don’t like it when women know more than they do. 6. They say that educating women has become beneficial and still is beneficial, being taught a good doctrine can in no way have a negative effect on anything. It is simply irrational. 7. Christine’s mother wanted her to do girly things, things that women should do such as spinning and weaving. On the other hand, her father wanted her to be educated and watch her learn and grow to become an intelligent young woman. This illustrates the clash between the Medieval and Renaissance worldviews because her mother wanted her to do things women â€Å"should† do and her father wanted her to do the opposite, by gaining an education. 8. The auses of misogyny are from men who are ignorant, these men blame women because they either hate women because they are simply far more intelligent than they are and naturally good hearted, others who hate women are crippled and the only way for them to impose their misery on others is by blaming women who make others happy, and finally men who have spent much of their young years sleeping around can’t anymore and they like to sabotage women’s lives by disgusting others because they canâ €™t enjoy sexual pleasures. I do think that all of these still exist in our society, as well as in others. For example, I had a discrepancy with a guy friend of mine, who is a boxer like I am and he had the idea that he could beat me; his reasoning for it was solely because I was a girl. He did not have any other valid reason as to why he could beat me, he didn’t bring in my statistics either, which made even more pathetic that he would think such a thing. Another example in our society is of a young man who was in college that contracted aids. This man went around the entire college campus sleeping with other women so that they would also have the disease without telling them prior to their relations. He was miserable, so he wanted to make other women feel his pain. I think these attitudes are rooted deep in our society and I’m not sure that they will ever go away. 9. They contribute much of civilizations advancements to Minerva, Isis, and Ceres. Isis was an Egyptian goddess, who has been mostly named as the goddess of rebirth. She was known for spending time amongst her people and taming men. She also taught women how to weave, grind corn, spin flax, and make bread. Minerva was a Roman goddess, who was associated with poetry, medicine, wisdom, weaving, crafts, war, artillery, and trading. It is said she developed numbers and musical instruments. Ceres was a Roman goddess also, she was known for being the goddess of agriculture and fertility of the land. 10. No I think Christine suggests that it shouldn’t be excluded from men. She implies in the first paragraph that if men read the truth they’d shut up, hold their tongues, and lower their heads in shame for such stupid ignorance. How to cite Christine de Pizan, Essay examples

Professional Practice Preparation for Recruitment - myassignmenthelp

Question: Discuss about theProfessional Practice Preparation for Recruitment Processes. Answer: Critique of recruitment processes used in information technology/business analysis The main asset of any business is its people and the performance of its people is the main determinant of the business success. Managing this asset of the business is known as human resource management. Recruitment process is an important part of human resource management and requires proper strategic planning for providing the organization with a pool of qualified candidates for choosing. Information Technology is the product of globalization that has taken up the job of making the working environment effective and therefore improving the rate of productivity. New doors have been open for the outside world and communication channels have become much easier and convenient. Because of that many business opportunities, avenues and jobs have opened up. The issue of maintaining records into files have been removed with the help of different applications and computers. IT has been acting as a gift for people so that they are able to work from any corner of the world. In this age of information, people who have an IT and engineering background have become in demand like never before. Foe helping differentiating and finding the right people for the team, staffing and recruitment agencies and individual specialists are there for placing talents (Rivera 2012). With advancements on the recruitment industry, the IT services companies also are bringing in improvements with large investments. The largest investments these companies are carrying out is in the automation of processes in their conventional businesses such as application and infrastructure management and business process outsourcing (BPO), which implies that less number of engineers would be necessary at the lower rung of the ladder. Leading IT sector companies like Wipro, TCS and Infosys are involved in mundane jobs like server maintenance, infrastructure management and client support and carried out large recruitment from engineering institutes across countries. This latest advancement of automation is, however, a threat to jobs for fresh graduates and college recruitments have reduced. For a long time automation has been bringing change in all the sectors and squeezing people, now turning its attention to IT. Companies have focused on the introduction of automation across their projects, even in the backdrop of price pressure in their traditional services. Automation is expected to better the operating margins of organizations. Automation might not be eliminating jobs immediately, instead bringing the focus of people on different forms of job, especially those that are high on creativity and thinking, and ask for human interaction. Therefore, even if one job gets eliminated, there are many more that would get created (Berman et al. 2012). Critique of my MBTI type ENTJ people are born leaders. People who have this kind of personality type embodies the traits of confidence and charisma, and project authority in ways that draw crowds together behind one common objective. However, contrasting their Feeling (F) equivalent, ENTJs are categorized by an often brutal standard of levelheadedness, making use of the drive, sharp minds and determination for achieving whatever end they have set themselves up for. I suppose that is the best thing that these kind of personality type only constitute for just three percent of the population, in case they overpower the more sensitive and timid type of personalities that constitute much of the rest of the world. However, ENTJs are to be thanked for a lot of businesses and institutions that are taken for granted every day (Kroeger and Thuesen 2013). ENTJs are believed to be loving a good challenge always, whether it is big or small and they are firm believers that if they have enough time and resources they have the capability of achieving any objective. This quality seen in ENTJ types make them brilliant entrepreneurs and their capability of thinking strategically and holding long term concentration would be executing every step of their goals with determination and precision, making them powerful business leaders. This determination is more often than note a self-fulfilling prophecy as it is inbuilt in ENTJs that they are pushing towards their goals with the help of complete willpower in situations where others might back out and move on. Their Extraverted (E) nature implies that they are most likely to be pushing everyone else besides them, making them achieve spectacular results in the process. At the negotiating table ENTJs are most of the time dominant, unforgiving and relentless. That is not because they vicious or cold hearted - it is more of the fact that they are genuinely enjoying the challenge, battling of wits, the repartee that is extracted from this environment. If in any case they cannot keep up then there is no reason for ENTJS to folding on their individual core tenet of the definite victory. If there is anyone whom the ENTJs actually admire and respect it is only those people who are able to stand up to them matching up to the intellect level, someone who is able to act with complete quality and precision that can match their own. ENTJ personalities show special skills in the recognition of other peoples talents and this is helpful in both team building and keeping ENTJs from displaying of excessive arrogance and condescension. However, they also possess a specific skill in the calling out of other peoples failures with unnatural degrees of insensitivity and this is where ENTJs actually begin running into trouble (Cohen, Ornoy and Keren 2013). Emotional expression is not the strong suit of any analyst kind, but due the presence of Extraverted (E) nature, ENTJs distance from their emotions is particularly public and is directly felt by a wider swath of people. Particularly in a professional environment, ENTJs would just crush the sensitivities of those they consider as being incompetent, inefficient or lazy. For people with ENTJ personality type, displaying of emotions is considered displaying of weakness and it is easier in making enemies with the help of this approach. It would be better for ENTJs in remembering that they are completely dependent on the functioning of team and not simply for achieving of goals but for their feedback and validation also, something ENTJs are extremely very sensitive to. Appraisal of the value of Post graduate study and international experience in information technology/business analysis In the IT and Business Analysis, completing post graduate study and international experience is of huge importance. It is supposed to be providing advanced knowledge on the subject for graduates, irrespective of the fact that there is prior knowledge of business or not. Post graduate studies on IT are good sources of introductory knowledge and has many advantages, like it does not ask for work experience as part of the admission, assists students in developing many kinds of skills and even includes practical experiences or internship opportunities. Worldwide post graduate courses are becoming popular and is supported by the fact that majority of the courses are offered in English. Most of the applicants for these post graduate courses have applicants from non-business undergraduates. The best advantage is that these courses a way of advancement for business knowledge immediately after graduation is done (Collis and Hussey 2013). Classic business masters ask for a considerable amount of initial work experience for admittance, however there are many that do not. These courses are good for providing a basic base for a great start to the career and assisting fresh graduates in their search for a good job in an incremental young job market that is saturating with high expectations. Most of the post graduate course are known for offering in-depth theoretical classes and there is the option of choosing from an extended range of interesting electives. There is even the option of learning a second language in some courses, which can act as a requirement of the course. Practical experiences in schools have made the international experience and course more versatile, just in line with the requirement of the present global employment market. International experiences provides the option of different opportunities for gaining international experience and travelling to several different countries for gaining insights from leading international experts. These post graduate co urses provide a diverse amount of knowledge related to different subjects, preparing future managers for understanding the complex interrelation among relevant topic and being able to contribute to relevant discussions. Post graduate courses and international exposure helps in the development of interpersonal skills, helps become a fast problem solver and apply theories to actual situations. These courses are at times cheaper than thought and are largely sought after. These kind of post graduate courses are offered worldwide and do not ask for only a special kind of graduate degree. It is a great opportunity for students who have just completed their graduation in any field and are open for a career progression (Rae and Woodier-Harris 2012). Analysis of 'Why ethics are important for professionals in information technology/business analysis' Today, professional ethics has become a very important part of the workplace. With time, as the professionals are becoming more and more specialized in their professional occupation, professional firms are increasingly becoming busier in the development, revision and refinement of professional code of ethics. Physicians, attorneys and other professionals, who are into jobs that have direct influence on the lives of other people are usually into the receiving of formal training that includes courses addressing ethical issues that are common to their professions. IT professionals and business analysts are often having access to different confidential knowledge and data regarding individuals and companies that provide them with a large deal of power. This power has the probability of getting abused, either inadvertently or deliberately. However, there exists no standard training requirements for becoming an expert IT professional and business analyst. Organizations and associations for IT professionals are starting to address the ethical concerns of their job, even though, there are no requirements for IT professionals and business analysts in belonging to these organizations (Crane and Matten 2016). The guideline and training of IT professionals normally focuses on technical data and aptitudes. They make sense of how to perform endeavours, yet with little idea of how those limits can be manhandled. Honestly, various IT professionals approach their work with a hacker's perspective: whatever you can do, you're met all requirements for do. As a matter of fact, various IT professionals don't comprehend that their occupations incorporate good issues. However various decisions are made once per day that raise moral issues. As an IT professional, one has the rights and advantages that allow to get to most of the data on the systems on the network. One may even have the ability to get to encrypted data in case they approach the recovery agent account. What they do with those limits depends to some degree on their particular occupation commitments and to some degree all alone good feelings about these issues (Bishop 2013). IT professionals who do work for different associations have extensively more good issues to oversee. By then there are money issues. The development of network strikes, hacks, viruses and diverse threats to their IT establishments have influenced numerous associations to be restless. As an IT professional, it may be anything other than hard to play on that fear to induce associations to spend substantially more money than they genuinely need to. Another ethical issue incorporates promising more than you can pass on, or controlling data to get higher charges. One can install technologies and configure settings to impact a client's network more to secure, be that as it may one can never make it absolutely secure. Not in the least like more settled, more settled purposes for living, for instance, medication and law, most good issues that IT professionals resist have not been arranged into law, nor is there a standard required oversight body, for instance, the national or state therapeu tic connection or bar association, that has set up an ordered code of ethics (Johnson 2014). References and Bibliography Baltzan, P., 2012.Business driven technology. McGraw-Hill/Irwin. Batchelor, R., Bobrowicz, A., Mackenzie, R. and Milne, A., 2012. Challenges of ethical and legal responsibilities when technologies uses and users change: social networking sites, decision-making capacity and dementia.Ethics and Information Technology,14(2), pp.99-108. Berman, E.M., Bowman, J.S., West, J.P. and Van Wart, M.R., 2012.Human resource management in public service: Paradoxes, processes, and problems. Sage. Bilbao-Osorio, B., Dutta, S. and Lanvin, B., 2013, April. The global information technology report 2013. InWorld Economic Forum(pp. 1-383). Bishop, W.H., 2013. The role of ethics in 21st century organizations.Journal of Business Ethics,118(3), pp.635-637. Cohen, Y., Ornoy, H. and Keren, B., 2013. MBTI personality types of project managers and their success: A field survey.Project Management Journal,44(3), pp.78-87. Collis, J. and Hussey, R., 2013.Business research: A practical guide for undergraduate and postgraduate students. Palgrave macmillan. Crane, A. and Matten, D., 2016.Business ethics: Managing corporate citizenship and sustainability in the age of globalization. Oxford University Press. Glodstein, D., 2014. Recruitment and retention: Could emotional intelligence be the answer.The Journal of New Business Ideas Trends,12(2), p.14. Johnson, J.A., 2014. From open data to information justice.Ethics and Information Technology,16(4), pp.263-274. Kroeger, O. and Thuesen, J.M., 2013.Type talk: The 16 personality types that determine how we live, love, and work. Dell. Rae, D. and Woodier-Harris, N., 2012. International entrepreneurship education: Postgraduate business student experiences of entrepreneurship education.Education+ Training,54(8/9), pp.639-656. Rivera, L.A., 2012. Hiring as cultural matching: The case of elite professional service firms.American Sociological Review,77(6), pp.999-1022. Schwalbe, K., 2015.Information technology project management. Cengage Learning. Stahl, G., Bjrkman, I., Farndale, E., Morris, S.S., Paauwe, J., Stiles, P., Trevor, J. and Wright, P., 2012. Six principles of effective global talent management.Sloan Management Review,53(2), pp.25-42. Yoo, Y., 2013. The tables have turned: How can the information systems field contribute to technology and innovation management research?.Journal of the Association for Information Systems,14(5), p.227.

The Great Gatsby - Male And Female Interactions Essays -

The Great Gatsby - Male and Female Interactions Through the interactions between male and female characters, Fitzgerald depicts a variety of social expectations regarding "typical" male behavior in the 1920's. In the novel The Great Gatsby, characters such as Tom Buchanan, Jay Gatsby, George Wilson and Nick Carraway demonstrate behavior that acts to maintain and live up to expectations inherent in society. Through their controlling ways, these characters strive to define the "typical" man in the 1920's. The notion that a man's success can be measured by his possessions becomes evident through the actions of Tom, Gatsby and Wilson. These characters strive to obtain more than just material possessions. For example, Tom seems to view the women in his life as mere possessions, a sign of his success and wealth. His attitude and interactions with Daisy, his wife, and Myrtle, his mistress, demonstrate this. Through out the story, Tom does not show respect or genuine caring for either woman. Rather, he commits open adultery with Myrtle. Tom makes this affair public because it is just another way of showing-off, another of his possessions and thus boosting his ego. Tom does this without regard for the shame his affairs may bring onto his wife. Daisy comes to represent a treasured and sought possession for both Tom and Gatsby. Although on the surface it appears that Gatsby has an ever-lasting love for Daisy, I feel that his longing for Daisy stems from his need to recapture a possession which he lost during his youth. Nick comments "He talked a lot about the past and I gathered that he wanted to recover something, some idea of himself perhaps, that had gone into loving Daisy" (117). Furthermore by possessing Daisy's love, Gatsby can reject defeat and feel successful as a man. In the novel, Gatsby goes as far as to view the green light as a symbolic way of holding onto his possession and keeping Daisy in some way close to him. After obtaining his dream of being reunited with Daisy, the green light begins to lose its symbolic strength. "Now it was again a green light on a dock. His count of enchanted objects had diminished by one" (98). Now that the realization of his dream has begun, Gatsby needs to feel a greater sense of possession or control over Daisy. He may feel the need to obtain another enchanted object to replace the loss of the symbolic meaning of the light. Now the only enchanted object which he is left to obtain is Daisy's complete and everlasting. Likewise, Tom refuses to forfeit Daisy to another man or even believe that she could love another. Tom states "But all the rest is a God damnened lie. Daisy loved me when she married me and she loves me now." (138). If Tom were to give up Daisy to another man, this would surely be a sign of defeat and failure like losing a football or polo trophy. Instead of admitting defeat, Tom rationalizes Daisy's behavior by demeaning her will. For example, he states "The trouble is that sometimes she gets foolish ideas in her head and doesn't know what she's doing" (138). Another social expectation of "typical" male behavior in the 1920's depicted in The Great Gatsby is the notion that a "real" man should be in control of the woman in his life at all times. This notion is exemplified through the struggling relationship between George and Myrtle Wilson. Although Fitzgerald describes George as "one of these worn-out men...He was his wife's man and not his own." (144), a need for control takes over George when he discovers his wife had "some sort of life apart from him in another world." (131) with perhaps another man. To gain control over this situation and thus live up to the social expectation, George takes drastic measures. He states "I've got my wife locked up in there. She's going to stay up there till the day after tomorrow and then we 're going to move away." (143). Through his actions, George forces his will on his wife and strives to maintain control over his possession, his wife. In addition, Tom demonstrates control over Myrtle when the issue of whether she has the right to

The aim of this research is, eventually, to Essays

The aim of this research is, eventually, to Essays The aim of this research is, eventually, to Essay The aim of this research is, eventually, to Essay Context of the intended research CRIT is a receptor that was foremost encountered on the surface of aSchistosomaspecies ; in theSchistosoma,it acts as a decoy C2-binding receptor in order to protect this parasite from complement onslaught by viing with C4 for the binding of C2 ( Inal and Schifferli, 2002 ) . Complement is, basically, an enzyme system that is triggered upon immune system onslaught: most of the enzymes in this system are identified through standardised labeling: they are labelled C followed by a figure and so a codification based on the cleavage merchandises when proteolysed, for illustration, C5b-9. Complement onslaught ( Carroll, 1998 ) plays a major function in supporting hosts from immune onslaught, in footings of extinguishing foreign encroachers, and involves a complex tract of interactions, in order that the procedure does non take to self devastation: so, unregulated complement action can take to autoimmune diseases ( Ohet al. ,2003 ) , and other conditions/diseases such as bosom onslaught ( K ilgoreet al. ,1994 ) , Alzheimer’s disease ( Bradtet al. ,1998 ) . CRIT ( or Sh-TOR as it was antecedently known ) was found inSchistosoma,as a complement C2 protein, that could barricade complement activation, therefore bring oning bilharzia in worlds ; it was hypothesized that the CRIT blocked complement activation through its C2 binding site ; CRIT look in the parasite therefore acts as a steerer C2 binding receptor, protecting the parasite against complement onslaught by viing with C4 for the binding of C2, at the ed1 sphere ( Hui, 2005 ) . CRIT has later been found that other animate beings, that are suited as theoretical account systems for analyzing CRIT action besides express CRIT, for illustration, the rat andTrypanosoma.Recent work has besides shown that worlds have a CRIT factor, labeled ( Hu ) -CRIT which is expressed in a broad scope of human cells, particularly in hematopoietic cells ( Inalet al. ,2005 ) . Further elaborate surveies of CRIT have shown that it is a transmembrane receptor with two extracellular and two in intracellular spheres with an active 11 amino-acid peptide subdivision ( called CRIT-H17 ) which is hypothesized to be involved in the complement suppression activity of CRIT ( Hui, 2005 ) . Much work has been undertaken on clarifying the mechanism of action of CRIT, in footings of it being a potentially utile molecule in handling immunological diseases and other diseases, such as malignant neoplastic disease. For illustration, Inalet Al.( 2005 ) have shown that CRIT barricading can take to deprotection in CRIT-expressing human myeloid cell lines and in monocytes, ensuing in a greater susceptibleness to complement-mediated lysisin vitro. Other research, such as that by Mollet Al.( 2006 ) has shown that CRIT look is different in patients with kidney upsets, through assorted alterations in up- or down-regulation of CRIT look, taking to the suggestion that the upregulation of CRIT in activated podocytes might stand for a self-defense mechanism, stand foring a ‘last line’ of defense mechanism in membranous kidney disease of the kidney. Other surveies have looked at the existent mechanism of operation of the CRIT tract, for illustration Huiet Al.( 2005 ) looked at the look of a functional recombinant von Willebrand factor-A sphere from human complement C2, in footings of this being a possible binding site for C4 and CRIT. As we have seen, CRIT competes with C4b for the binding of C2, with the major adhering site on C2 being located on a short peptide sequence that was antecedently of unknown beginning ; Huiet al. ,( 2005 ) , nevertheless, looked at a part on C2 that was known to hold binding capacity, the von Willebrand Factor-A, and found that, so, this peptide sequence inhibits complement activity ; utilizing a cloned von Willebrand Factor-A sequence, Huiet Al.( 2005 ) were able to look in item at the interactions between C2 and CRIT and C4b. This pilot survey that is intended to be undertaken as portion of this reappraisal of CRIT is intended to take this work of Huiet Al.( 2005 ) farther. As will be seen, on adh ering the serum complement protein, C2, the CRIT peptide, H17 can cut down complement-mediated redness in vivo [ 7 ] and it is intended that CRIT-ed1 and H17 will be tested as possible distinction therapeutics peculiarly aiming monocytic leukemia. To better the efficaciousness of these peptides, structural information on the manner they interact with C2, such that this can be ‘tweaked’ to increase efficiency of binding. The CRIT-H17 peptide will be synthesized full length as an 11-mer, but besides as a 10-mer, 9-mer and 8-mer. We will besides mutate to alanine the amino acids believed to interact with the vWFA sphere of C2. CRIT-H17 will farther be synthesized as a head-to-toe cyclised version of H17 ( to mime the native CRIT molecule ) . Prior to the structural surveies, nevertheless, these peptides will be tested for their efficaciousness at cut downing complement activationin vitro. In add-on, interactions of these peptides with C2 vWFA sphere will be monitored for by a novel technique utilizing electrospray ionization mass spectroscopy ( developed within the Institute for Health Research A ; Policy at LMU by Dr. A. Bligh ) [ 8 ] . This technique can besides observe the presence of two adhering sites and if there are two ligands whether they bind competitively and with what affinity. To supervise conformational alterations on interaction, in add-on to working out dynamicss of interaction, we will utilize Double Polarisation Interferometry ( AnaLight Quantum ) through coaction with Dr. R.B. Sim ( MRC Immunochemistry Unit, Univ. of Oxford ) . Prof. Peter Gros ( Centre for Biomolecular Research, Utrecht ) has approached the applier for CRIT peptides for co-crystallisation with an available C2a ( von Willebrand Factor A [ vWFA ] and serine peptidase ) concept and we expect this coaction to continue and to finally demo the points of contact between CRIT-ed1 and C2 ( via the vWFA sphere ) . It is hoped that this methodological analysis will let a deeper apprehension of how CRIT binds with other molecules in the complement tract, and how this tract is regulated in footings of supplying a intervention option for some of the diseases/conditions that are known to develop following perturbation, or irregular operation of, this complement tract. Introduction The purpose of this research is, finally, to transport out a pilot survey to back up preliminary grounds that the complement receptor CRIT ( Complement C2 Receptor Inhibitor Trispanning ) plays a function in monocyte/macrophage terminal distinction. We aim to demo that by triping distinction through CRIT, it is possible to suppress the proliferation of myeloid leukemia cells. This could hold of import deductions for an alternate intervention agenda for monocytic leukemia. By the terminal of this survey we expect to demo the undermentioned: I ) that monocytes which can adhere C2 through CRIT maintain monocytic phenotypein vitroorin vivo ;II ) that monocytes can be induced to terminally distinguish by barricading the interaction of CRIT with its blood relation ligand, complement C2 or as monocytes move into an extravascular environment devoid of C2 ; that a knockdown of CRIT look in monocyte carcinoma cell lines or physical blocking of CRIT-C2 interaction induces them to terminally dis tinguish, and that, likewise, a blocking of CRIT-C2 interaction on leukaemic monocytes will halt proliferation and bring on distinction ; and, in conclusion, that, conversely, monocytes that are C2-/- , can non be induced to terminally distinguish by barricading the interaction of CRIT with its ligand, C2, nevertheless on traveling into an extravascular environment, other excess mechanisms, such as interaction of monocyte integrins with VCAM molecules on endothelial cells, may still bring on distinction. In consequence, basically, either barricading ligand interaction with CRIT or cut downing CRIT look should excite cell rhythm apprehension ( irreversible block at G1 ) and terminal distinction into cells with a macrophage phenotype. These conditions represent a fresh tract for monocyte/macrophage terminal distinction, based on the theoretical account proposed, and affecting the complement receptor, CRIT. In footings of monocyte leukemia, besides advancing cell rhythm apprehension, barricading CRIT with anti-CRIT-ed1 has the added benefit of rendering the cell more susceptible to complement-mediated cytolysis, as described antecedently for monocyte carcinoma cell lines ( U937 and THP-1 ) and primary monocytes showing CRIT [ 1 ] . It is intended that this research will lend to a deeper apprehension of how the complement tract works in worlds, in peculiar with respect to how abnormalities in the operation of the complement tract can do disease, and how CRIT look modulates the operation of the complement tract in human systems. The informations obtained from this pilot survey will be used to look into five chief issues: I ) The function of CRIT in myeloid distinction The function of CRIT in myeloid distinction has been studied with an antagonist CRIT-based peptide termed H17 ( NH2-HEVKIKHFSPY-CO2H ) consisting the 11aa C-terminus of CRIT-ed1. Preliminary work suggests that in adhering to C2 and therefore barricading the interaction of C2 with CRIT [ 1 ] , H17 may bring on the distinction of monocytes/promonocytic cell lines along the tract of macrophage distinction, and significantly, inhibit cell proliferation. The different curative attacks that are presently used in handling acute leukemia include cytotoxicity, programmed cell death and distinction. Differentiation therapy was developed over a decennary ago and Acts of the Apostless by bring oning cell rhythm apprehension and hence distinction in leukaemic monocytes [ 2 ] , therefore elegantly avoiding cytotoxicity effects. Retinoids, such as all-trans-retinoic acid ( ATRA ) are used to handle promyelocytic leukemia by specifically aiming neoplastic cells whilst non impacting normal mature ce lls. Many successes in the intervention of monocytic leukaemias have been reported since [ 3-5 ] . We suggest that a CRIT-based peptide ( H17 or an H17 derived function ) could finally offer an of import alternate intervention for monocytic leukemia by bring oning distinction of monocytic cells. The peptide will be tested entirely and in combination with ATRA in a mouse theoretical account of acute promyelocytic leukemia [ 6 ] . two ) The construction of CRIT peptides ( ed1 and H17 ) and of CRIT peptides interacting with the von Willebrand Factor A ( vWFA ) sphere of complement C2 On adhering the serum complement protein, C2, the CRIT peptide, H17 can cut down complement-mediated redness in vivo [ 7 ] and we will prove CRIT-ed1 and H17 as possible distinction therapeutics peculiarly aiming monocytic leukemia. To better the efficaciousness of these peptides, we aim to utilize structural information on the manner they interact with C2. The CRIT-H17 peptide will be synthesized full length as an 11-mer, but besides as a 10-mer, 9-mer and 8-mer. We will besides mutate to alanine the amino acids believed to interact with the vWFA sphere of C2. CRIT-H17 will farther be synthesized as a head-to-toe cyclised version of H17 ( to mime the native CRIT molecule ) . Prior to structural surveies, these peptides will be tested for their efficaciousness at cut downing complement activation in vitro. Interactions of these peptides with C2 vWFA sphere will be monitored for by a novel technique utilizing electrospray ionization mass spectroscopy ( developed within the Institute for Health Research A ; Policy at LMU by Dr. A. Bligh ) [ 8 ] . This technique can besides observe the presence of two adhering sites and if there are two ligands whether they bind competitively and with what affinity. To supervise conformational alterations on interaction, in add-on to working out dynamicss of interaction, we will utilize Double Polarisation Interferometry ( AnaLight Quantum ) through coaction with Dr. R.B. Sim ( MRC Immunochemistry Unit, Univ. of Oxford ) . Prof. Peter Gros ( Centre for Biomolecular Research, Utrecht ) has approached the applier for CRIT peptides for co-crystallisation with an available C2a ( von Willebrand Factor A [ vWFA ] and serine peptidase ) concept and we expect this coaction to continue and to finally demo the points of contact between CRIT-ed1 and C2 ( via the vWFA sphere ) . three ) Expression profile of CRIT in autoimmune disease and malignant neoplastic disease With a position to understanding the function of CRIT in autoimmune disease and malignant neoplastic disease, the applier is join forcesing on a Swiss National Foundation funded undertaking with Prof. J. Schifferli ( Univ. Hospital Basel ) to do a CRIT smasher mouse. To happen an association between CRIT look degrees and the disease procedure, a comparing of CRIT look ( messenger RNA and protein ) in normal tissue with that in autoimmune disease and malignant neoplastic disease will be made. In situ hybridization surveies every bit good as immunohistochemistry, utilizing dual staining and/or staining of consecutive subdivisions with anti-CRIT and cell specific markers, will be conducted to corroborate look in sertoli cells, podocyte cells, keratinocytes, encephalon [ 1 ] . The distribution of CRIT in normal and morbid tissue will be studied, peculiarly tissues injured by inflammatory or necrotic procedures: joints-synovium in arthritis, myocardial infarction etc. Previously, we carri ed out a survey along these lines, which looked at CRIT look in assorted kidney diseases [ 9 ] . This survey revealed CRIT upregulation in membranous kidney diseases on glomerular podocyte cells. Unlike CR1, hitherto the lone other complement regulator described on podocytes, and which is non upregulated in membranous nephropathy, we believe that CRIT on podocytes represents a last line of defense mechanism against onslaught by complement. Functional information back uping this was later obtained ( manuscript in Complement regulators are frequently upregulated in malignant neoplastic disease [ 10 ] and so expression degrees of CRIT in assorted human malignances will be assessed excessively. Critically, CRIT is upregulated in liver malignant neoplastic disease ( Fig. 4 ) and thyroid malignant neoplastic disease ( non shown ) . As obstruction of CRIT with antibody sensitises cells to complement lysis [ 1 ] , such findings may hold applications in malignant neoplastic disease. Already schemes to barricade complement regulators with specific antibodies have been used successfully with a position to developing fresh malignant neoplastic disease immunotherapies [ 11,12 ] . In a recent development, membrane-bound complement regulative proteins ( mCRP ) have been downregulated by siRNA to render tumour cells sensitive to complement [ 13 ] . Therefore we will bring forth vector-based shRNAs ( utilizing psiRNA vector [ In vivo Gen ] ) to stably strike hard down CRIT look and see the consequence on tumor cells. four ) CRIT extracellular peptide ( H17 ) and its usage in modulating complement-mediated redness in in vivo theoretical accounts of autoimmune disease With a position to therapeutically suppress redness due to classical tract activation in theoretical accounts of complement-mediated autoimmune disease, CRIT has been targeted to suppress the Reversed Passive Arthus Reaction in mice [ 7 ] . By disposal of an counter peptide, H17, which binds complement C2 and prevents its activation it was possible to significantly cut down complement-mediated redness. To prove this peptide as a curative against autoimmune diseases in which the classical tract is peculiarly of import we are join forcesing with labs that have the appropriate animate being theoretical accounts. Experimental autoimmune myasthenia gravis ( EAMG ) is an antibody-mediated autoimmune disease impacting the neuromuscular junction. The disease, which is besides T cell-dependent, is an accurate theoretical account in footings of its pathology and clinical result of human myasthenia gravis ( MG ) . We have been approached by Prof. P. Christadoss and Dr. E. Tuzun of the Universit y of Texas, Galveston to prove H17 in their mouse theoretical account of MG [ 14,15 ] and will continue with this coaction. 1.2.5 Does CRIT adhere other serum proteins through its extracellular spheres? In a collaborative survey with Prof. Marina Botto ( Imperial College ) we will look into whether CRIT is a receptor for any other proteins beside complement C2 and FB, with which it binds with high and low affinity, severally. To prove whether the extracellular spheres of CRIT have other adhering spouses, receptor affinity chromatography [ 16 ] will be used to see whether ed1 binds other proteins from the serum of a C2 deficient ( C2D ) patient or of a combined C2/FB smasher mouse [ 17,18 ] . As the function of the 2nd extracellular sphere, ed2 has non been established, normal serum will be used ab initio to place ed2-binding proteins adhering to ed2 affinity columns by standard mass-spec designation protocols. Further experiments will be conducted to see if CRIT binds integrins. The principle for this is that CRIT-ed1 binds the vWFA1 sphere of complement C2 [ 19 ] and vWFA spheres are typically found in integrins, such as Very Late Antigen 4 ( VLA-4 ) on monocytes. The interaction w ith vascular cell adhesion molecule-1 ( VCAM-1 ) molecules on the endothelium is believed to non merely intercede attachment [ 20 ] and transendothelial migration [ 21 ] but besides to excite distinction [ 22 ] . Methodology to be utilized in the survey of the purposes of the undertaking: I ) The function of CRIT in myeloid distinction As we have seen, the function of CRIT in myeloid distinction has been studied with an antagonist CRIT-based peptide termed H17 ( NH2-HEVKIKHFSPY-CO2H ) consisting the 11aa C-terminus of CRIT-ed1. Preliminary work suggests that in adhering to C2 and therefore barricading the interaction of C2 with CRIT [ 1 ] , H17 may bring on the distinction of monocytes/promonocytic cell lines along the tract of macrophage distinction, and significantly, inhibit cell proliferation. It is intended that this pilot survey will go on the work that has been started in this respect, and will lend original research findings to the intervention of diseases that are caused by failures in the proper operation of the complement tract in worlds. The different curative attacks that are presently used in handling acute leukemia include cytotoxicity, programmed cell death and distinction. Differentiation therapy was developed over a decennary ago and Acts of the Apostless by bring oning cell rhythm apprehension and hence distinction in leukaemic monocytes [ 2 ] , therefore elegantly avoiding cytotoxicity effects. Retinoids, such as all-trans-retinoic acid ( ATRA ) are used to handle promyelocytic leukemia by specifically aiming neoplastic cells whilst non impacting normal mature cells. Many successes in the intervention of monocytic leukaemias have been reported since [ 3-5 ] . We suggest that a CRIT-based peptide ( H17 or an H17 derived function ) could finally offer an of import alternate intervention for monocytic leukemia by bring oning distinction of monocytic cells. The peptide will be tested entirely and in combination with ATRA in a mouse theoretical account of acute promyelocytic leukemia [ 6 ] . This will take to cons equences which could be of great usage in developing alternate therapies for handling conditions that arise as a consequence of failure of the right operation of the complement tract in worlds. two ) The construction of CRIT peptides ( ed1 and H17 ) and of CRIT peptides interacting with the von Willebrand Factor A ( vWFA ) sphere of complement C2 As has been seen, Huiet Al.( 2005 ) looked at the look of a functional recombinant von Willebrand factor-A sphere from human complement C2, in footings of this being a possible binding site for C4 and CRIT. As we have seen, CRIT competes with C4b for the binding of C2, with the major adhering site on C2 being located on a short peptide sequence that was antecedently of unknown beginning ; Huiet al. ,( 2005 ) , nevertheless, looked at a part on C2 that was known to hold binding capacity, the von Willebrand Factor-A, and found that, so, this peptide sequence inhibits complement activity ; utilizing a cloned von Willebrand Factor-A sequence, Huiet Al.( 2005 ) were able to look in item at the interactions between C2 and CRIT and C4b. The current survey will take the work of Huiet Al.( 2005 ) further, by looking in item at the CRIT tract, in footings of adhering the serum complement protein, C2, the CRIT peptide, H17 can cut down complement-mediated rednessin vivo[ 7 ] and we will prove CRIT-ed1 and H17 as possible distinction therapeutics peculiarly aiming monocytic leukemia. To better the efficaciousness of these peptides, we aim to utilize structural information on the manner they interact with C2. The CRIT-H17 peptide will be synthesized full length as an 11-mer, but besides as a 10-mer, 9-mer and 8-mer. We will besides mutate to alanine the amino acids believed to interact with the vWFA sphere of C2. CRIT-H17 will farther be synthesized as a head-to-toe cyclised version of H17 ( to mime the native CRIT molecule ) . Prior to structural surveies, these peptides will be tested for their efficaciousness at cut downing complement activation in vitro. Interactions of these peptides with C2 vWFA sphere will be moni tored for by a novel technique utilizing electrospray ionization mass spectroscopy ( developed within the Institute for Health Research A ; Policy at LMU by Dr. A. Bligh ) [ 8 ] . This technique can besides observe the presence of two adhering sites and if there are two ligands whether they bind competitively and with what affinity. To supervise conformational alterations on interaction, in add-on to working out dynamicss of interaction, we will utilize Double Polarisation Interferometry ( AnaLight Quantum ) through coaction with Dr. R.B. Sim ( MRC Immunochemistry Unit, Univ. of Oxford ) . Prof. Peter Gros ( Centre for Biomolecular Research, Utrecht ) has approached the applier for CRIT peptides for co-crystallisation with an available C2a ( von Willebrand Factor A [ vWFA ] and serine peptidase ) concept and we expect this coaction to continue and to finally demo the points of contact between CRIT-ed1 and C2 ( via the vWFA sphere ) . three ) Expression profile of CRIT in autoimmune disease and malignant neoplastic disease With a position to understanding the function of CRIT in autoimmune disease and malignant neoplastic disease, the applier is join forcesing on a Swiss National Foundation funded undertaking with Prof. J. Schifferli ( Univ. Hospital Basel ) to do a CRIT smasher mouse. To happen an association between CRIT look degrees and the disease procedure, a comparing of CRIT look ( messenger RNA and protein ) in normal tissue with that in autoimmune disease and malignant neoplastic disease will be made. In situ hybridization surveies every bit good as immunohistochemistry, utilizing dual staining and/or staining of consecutive subdivisions with anti-CRIT and cell specific markers, will be conducted to corroborate look in sertoli cells, podocyte cells, keratinocytes, encephalon [ 1 ] . The distribution of CRIT in normal and morbid tissue will be studied, peculiarly tissues injured by inflammatory or necrotic procedures: joints-synovium in arthritis, myocardial infarction etc. Previously, we carri ed out a survey along these lines, which looked at CRIT look in assorted kidney diseases [ 9 ] . This survey revealed CRIT upregulation in membranous kidney diseases on glomerular podocyte cells. Unlike CR1, hitherto the lone other complement regulator described on podocytes, and which is non upregulated in membranous nephropathy, we believe that CRIT on podocytes represents a last line of defense mechanism against onslaught by complement. Functional information back uping this was later obtained ( manuscript in Complement regulators are frequently upregulated in malignant neoplastic disease [ 10 ] and so expression degrees of CRIT in assorted human malignances will be assessed excessively. Critically, CRIT is upregulated in liver malignant neoplastic disease ( Fig. 4 ) and thyroid malignant neoplastic disease ( non shown ) . As obstruction of CRIT with antibody sensitises cells to complement lysis [ 1 ] , such findings may hold applications in malignant neoplastic disease. Already schemes to barricade complement regulators with specific antibodies have been used successfully with a position to developing fresh malignant neoplastic disease immunotherapies [ 11,12 ] . In a recent development, membrane-bound complement regulative proteins ( mCRP ) have been downregulated by siRNA to render tumour cells sensitive to complement [ 13 ] . Therefore we will bring forth vector-based shRNAs ( utilizing psiRNA vector [ In vivo Gen ] ) to stably strike hard down CRIT look and see the consequence on tumor cells. four ) CRIT extracellular peptide ( H17 ) and its usage in modulating complement-mediated redness in in vivo theoretical accounts of autoimmune disease With a position to therapeutically suppress redness due to classical tract activation in theoretical accounts of complement-mediated autoimmune disease, CRIT has been targeted to suppress the Reversed Passive Arthus Reaction in mice [ 7 ] . By disposal of an counter peptide, H17, which binds complement C2 and prevents its activation it was possible to significantly cut down complement-mediated redness. To prove this peptide as a curative against autoimmune diseases in which the classical tract is peculiarly of import we are join forcesing with labs that have the appropriate animate being theoretical accounts. Experimental autoimmune myasthenia gravis ( EAMG ) is an antibody-mediated autoimmune disease impacting the neuromuscular junction. The disease, which is besides T cell-dependent, is an accurate theoretical account in footings of its pathology and clinical result of human myasthenia gravis ( MG ) . We have been approached by Prof. P. Christadoss and Dr. E. Tuzun of the Universit y of Texas, Galveston to prove H17 in their mouse theoretical account of MG [ 14,15 ] and will continue with this coaction. 1.2.5 Does CRIT adhere other serum proteins through its extracellular spheres? In a collaborative survey with Prof. Marina Botto ( Imperial College ) we will look into whether CRIT is a receptor for any other proteins beside complement C2 and FB, with which it binds with high and low affinity, severally. To prove whether the extracellular spheres of CRIT have other adhering spouses, receptor affinity chromatography [ 16 ] will be used to see whether ed1 binds other proteins from the serum of a C2 deficient ( C2D ) patient or of a combined C2/FB smasher mouse [ 17,18 ] . As the function of the 2nd extracellular sphere, ed2 has non been established, normal serum will be used ab initio to place ed2-binding proteins adhering to ed2 affinity columns by standard mass-spec designation protocols. Further experiments will be conducted to see if CRIT binds integrins. The principle for this is that CRIT-ed1 binds the vWFA1 sphere of complement C2 [ 19 ] and vWFA spheres are typically found in integrins, such as Very Late Antigen 4 ( VLA-4 ) on monocytes. The interaction w ith vascular cell adhesion molecule-1 ( VCAM-1 ) molecules on the endothelium is believed to non merely intercede attachment [ 20 ] and transendothelial migration [ 21 ] but besides to excite distinction [ 22 ] . CRIT is a receptor that was foremost encountered on the surface of aSchistosomaspecies ; in theSchistosoma,it acts as a decoy C2-binding receptor in order to protect this parasite from complement onslaught by viing with C4 for the binding of C2 ( Inal and Schifferli, 2002 ) . Complement is, basically, an enzyme system that is triggered upon immune system onslaught: most of the enzymes in this system are identified through standardised labeling: they are labelled C followed by a figure and so a codification based on the cleavage merchandises when proteolysed, for illustration, C5b-9. Complement onslaught ( Carroll, 1998 ) plays a major function in supporting hosts from immune onslaught, in footings of extinguishing foreign encroachers, and involves a complex tract of interactions, in order that the procedure does non take to self devastation: so, unregulated complement action can take to autoimmune diseases ( Ohet al. ,2003 ) , and other conditions/diseases such as bosom onslaught ( K ilgoreet al. ,1994 ) , Alzheimer’s disease ( Bradtet al. ,1998 ) . CRIT ( or Sh-TOR as it was antecedently known ) was found inSchistosoma,as a complement C2 protein, that could barricade complement activation, therefore bring oning bilharzia in worlds ; it was hypothesized that the CRIT blocked complement activation through its C2 binding site ; CRIT look in the parasite therefore acts as a steerer C2 binding receptor, protecting the parasite against complement onslaught by viing with C4 for the binding of C2, at the ed1 sphere ( Hui, 2005 ) . CRIT has later been found that other animate beings, that are suited as theoretical account systems for analyzing CRIT action besides express CRIT, for illustration, the rat andTrypanosoma.Recent work has besides shown that worlds have a CRIT factor, labeled ( Hu ) -CRIT which is expressed in a broad scope of human cells, particularly in hematopoietic cells ( Inalet al. ,2005 ) . Further elaborate surveies of CRIT have shown that it is a transmembrane receptor with two extracellular and two in intracellular spheres with an active 11 amino-acid peptide subdivision ( called CRIT-H17 ) which is hypothesized to be involved in the complement suppression activity of CRIT ( Hui, 2005 ) . Much work has been undertaken on clarifying the mechanism of action of CRIT, in footings of it being a potentially utile molecule in handling immunological diseases and other diseases, such as malignant neoplastic disease. For illustration, Inalet Al.( 2005 ) have shown that CRIT barricading can take to deprotection in CRIT-expressing human myeloid cell lines and in monocytes, ensuing in a greater susceptibleness to complement-mediated lysisin vitro. Other research, such as that by Mollet Al.( 2006 ) has shown that CRIT look is different in patients with kidney upsets, through assorted alterations in up- or down-regulation of CRIT look, taking to the suggestion that the upregulation of CRIT in activated podocytes might stand for a self-defense mechanism, stand foring a ‘last line’ of defense mechanism in membranous kidney disease of the kidney. Introduction The purpose of this research is, finally, to transport out a pilot survey to back up preliminary grounds that the complement receptor CRIT ( Complement C2 Receptor Inhibitor Trispanning ) plays a function in monocyte/macrophage terminal distinction. We aim to demo that by triping distinction through CRIT, it is possible to suppress the proliferation of myeloid leukemia cells. This could hold of import deductions for an alternate intervention agenda for monocytic leukemia. By the terminal of this survey we expect to demo the undermentioned: I ) that monocytes which can adhere C2 through CRIT maintain monocytic phenotypein vitroorin vivo ;II ) that monocytes can be induced to terminally distinguish by barricading the interaction of CRIT with its blood relation ligand, complement C2 or as monocytes move into an extravascular environment devoid of C2 ; that a knockdown of CRIT look in monocyte carcinoma cell lines or physical blocking of CRIT-C2 interaction induces them to terminally dis tinguish, and that, likewise, a blocking of CRIT-C2 interaction on leukaemic monocytes will halt proliferation and bring on distinction ; and, in conclusion, that, conversely, monocytes that are C2-/- , can non be induced to terminally distinguish by barricading the interaction of CRIT with its ligand, C2, nevertheless on traveling into an extravascular environment, other excess mechanisms, such as interaction of monocyte integrins with VCAM molecules on endothelial cells, may still bring on distinction. In consequence, basically, either barricading ligand interaction with CRIT or cut downing CRIT look should excite cell rhythm apprehension ( irreversible block at G1 ) and terminal distinction into cells with a macrophage phenotype. These conditions represent a fresh tract for monocyte/macrophage terminal distinction, based on the theoretical account proposed, and affecting the complement receptor, CRIT. In footings of monocyte leukemia, besides advancing cell rhythm apprehension, barricading CRIT with anti-CRIT-ed1 has the added benefit of rendering the cell more susceptible to complement-mediated cytolysis, as described antecedently for monocyte carcinoma cell lines ( U937 and THP-1 ) and primary monocytes showing CRIT [ 1 ] . Bradt, B.M.et al. ,1998. Complement-dependent proinflammatory belongingss of the Alzheimer’s disease B-peptide.J. Exp. Med.188, pp.431. Carroll, M.C. , 1998. The function of complement and complement receptors in initiation and ordinance of unsusceptibility.Ann Rev Immun16,pp.545-568. Hui, K-M. , 2005. Biochemical and functional surveies of a fresh complement inhibitor, CRIT, with its interaction spouses. Dissertation submitted to the University of Basel, 2005. Hui, K-M.et al. ,2005. Expression of functional recombinant von Willebrand factor-A sphere from human complement C2: a possible binding site for C4 and CRIT.Biochem J.389, pp.863-868. Inal, J.M. , 2005. Complement C2 receptor inhibitor trispanning: from adult male to schistosome.Springer Seminars in Immunology27 ( 3 ), pp.320-331. Inal, J.M.et al. ,2005. Complement C2 receptor inhibitor trispanning: a fresh human complement inhibitory receptor.Journal of Immunology74, pp.356-366. Inal, J.M. and Schifferli, J.A. , 2002. Complement C2 receptor inhibitor trispanning and the B-chain of C4 portion a binding site for complement C2.Journal of Immunology168, pp.5213-5221. Kilgore, K.S.et al. ,1994. The complement system in myocardial ischaemia/reperfusion hurt.Cardiovasc Research28, pp.437. Makrides, S.C.et al. ,1992. Cell surface look of the C3b/C4b receptor ( CR1 ) protects the hamster ovary cells from lysis by human complement.J.Biol.Chem.34, pp.24754-24761. Moll, S.et al. ,2006. CRIT is expressed on podocytes in normal human kidney and upregulated in membranous kidney disease.Kidney International69,pp.1961-1968. Oh, K-S.et al. ,2003. Inhibition of complement activation by recombinant Sh-CRIT-ed1 parallels.Immunology110, pp.73-79.

Political climate of Venezuela Essay Example | Topics and Well Written Essays - 250 words

Political climate of Venezuela - Essay Example Various articulations in regards to democracy have been under the limelight, keeping in mind that political unrest violence is the main issue that brings about further curtailment of democracy in this nation. Venezuela is among the countries that take into account the virtue of multiparty and hence leading to the imposition of martial law as well as curtailing democratic rights in Venezuela. The United States of America that is the superpower has been against those people in support of President Chavez, who has been at large providing leadership full of poor governance. Elections held in the year 2012 was full of conspicuous results in that the Venezuela government have been forced out to permit the essence of the audit which is known to have been articulated fraudulent activities hence this could in turn help in revising the outcome of the elections (Valente, 23-29). Political unrest has been the subject as far as the political climate of Venezuela is of concern. Chavez on the other hand in his regime has worked diligently to make sure that his supporters believe that what he has achieved in his political system was not through deception and collusion with independent media. Some of the crucial negative insist that Venezuela political system has deployed includes the termination of popular Chavista social programs well known as Misiones Bolivarianas should the opposition takes into account the victory on the prevailing elections. I concur with L Philharmonic under heavy criticism over political climate of Venezuela.

Jaguar Land Rover Management Essay Example | Topics and Well Written Essays - 4000 words

Jaguar Land Rover Management - Essay Example Supply chain is defined as the a system involving the use of information, activities, people, organization and resources that work to ensure that products or services is moved from the supplier to the consumer. They are the link between the supplier and the consumer by ensuring that the supplier gets the goods to the target market and that the consumer can easily access the goods and services they need with ease. With this in mind, supply chain management would therefore refer to all attempts by the management and planning department of an organization to procure, coordinate, and convert and all other management activities that will ensure the success of the supply. It fosters coordination of activities with and across the various sectors of production, transportation, storage and distribution of goods and services. Channel partners may include intermediaries, suppliers, service provider and consumers which form a chain-like link through which the producer and the consumer are connec ted.Supply chain management has continued to be the most convenient way through which organizations can be able to gain knowledge they need in decision making (Wu & Blackhurst, 2009). The decision making process includes all activities which help us make informed choices that will lead to the overall success of the organization. In the automotive sector, there has been consumer demand for better quality product which meets the client needs of security, comfort, class, and has reduced negative effects on the environment

Basically Good, Bad, or Both Essay Example | Topics and Well Written Essays - 750 words

Basically Good, Bad, or Both - Essay Example Human beings are a combination of both, good and evil because they are neutral and they have the free will and determination to adopt any. In order to be civilized humans have set boundaries and rules that determine good and evil. Aristotle argued that since man is a social animal and setting boundaries for good and evil is but natural because they are essential for humans remain civilized. Humans are neutral because they are equally capable and free to make a rational choice between good and evil. It is the society, upbringing and biological factors that affect a human's ability to think and decide. So it's these factors that are to be accredited blamed or for good or evil, respectively. It has been proved that the human mind is not a blank slate by Steven Pinker in his book "The Blank Slate" and the other factors like the surroundings, sociological and biological factors affect the mind's ability to think. Humans are not born good or born evil because they are capable of both as th ey grow up into adults. Education and guidance have an effect on the mind's capability to decide and choose between good and evil. ... Whereas, the developed world is a different scenario and people are usually educated and well- brought up even well-fed and well-provided with all the needs and wants and it's a fact that these people are sensitive and have made rational decisions to do good and avoid evil. Both the qualities of good and evil are present within us and we must make a choice. There are outside influences that affect the nature of the choice. The most controversial example is George W. Bush who is civilized and a good man in the eyes of many and especially his relatives but he is responsible for waging wars for oil and millions have been killed in his quest. He is a combination of good and evil. Bush is a good person to some people and maybe he himself believes that he is working in the best interests of his people and his country. But the fact remains that his actions were evil and millions of innocent lives have been lost. There is a reason for human nature to take this form and there are several theo ries to explain it. The philosophical naturalism believes that humans are superior beings and they are the result of evolution. Humanist philosophers argue that good and evil are simply labels and made up boundaries in order to civilize this world. It is the brain and the society at work that bring out this distinction. These influences affect our decisions to be good or to be evil. Man was born free and free will according to Thomism by Aquinas explains that a free will is the only essential proof of the existence of a soul. Aristotle supported this theory as well since according to his concept of hylomorphism the soul is significant and also universal and the soul makes every human being different. Therefore, when every one of us is different, every one of us has a

Country Comparison of Economic Development Data

Country Comparison of Economic Development Data QUESTIONS: You are required to collect comprehensive economic development data for year 2012 2013 of Malaysia and two countries of your choice and discuss which country is better in terms of†¦Ã¢â‚¬ ¦(based on economic performance da ta collected) and discuss possible ways to improve your country’s economic development and standard of living. Malaysia Malaysia have 4 types of GDP which is purchasing power parity, official exchange rate, real growth rate and per capita PPP. For purchasing power parity in 2012 estimation is $501.5 billion and in 2013 estimation is $525 billion. In 2012 and 2013 estimation for the official exchange rate is $312.4 billion. For the real growth rate in 2012 estimation is 5.6% and in 2013 estimation is 4.7%. For the per capita PPP in 2012 is $17,000 and 2013 estimation is $17,500. Besides that, Malaysia have many different economy categories such as unemployment rate, population below poverty line. For the unemployment rate in 2012 estimation is 3% and in 2013 estimation is 3.1%. For the population below poverty line in 2012 and 2013 estimation is at 4.0% . Furthermore, for the budget consists of 2 categories which are revenues and expenditures. For the revenues in 2012 and 2013 estimation is $ 65.72 billion. For the expenditures in 2012 and 2013 estimation is $ 79.4 billion. In conjunction with the budget expenditures there is taxes which applies on the expenditures as well. For the taxes and other revenues is 21% GDP and for the budget deficit is -4.4% of GDP. For the consumer prices will have inflation rate as well. In 2012 estimation is 1.7% and in 2013 estimation is 2.2%. Lastly is the exports and imports for the country in Malaysia. For the exports in 2012 estimation is $227.7 billion and in 2013 estimation is $230.7 billion. For the imports in 2012 estimation is $186.9 billion and in 2013 estimation is $192.9 billion. The next category is people and society. There is 5 categories which is population, human development index, human poverty index, poverty rates and population growth rates. For the population in Malaysia for 2012 and 2013 estimation is 30,073,353 people. For the human development index in 2012 and 2013 estimation is 0.769. For the poverty rates in 2012 and 2013 estimation is 1.7%. Finally, for the population growth rates in 2012 and 2013 estimation 1.7%. Finally, for the population growth rates in 2012 and 2013 estimation is 1.47%. Japan Japan have 4 types of GDP which is purchasing power parity, official exchange rate, real growth rate and per capita PPP. For purchasing power parity in 2012 estimation is $4.638 trillion and in 2013 estimation is $4.729 trillion. In 2012 and 2013 estimation for the official exchange rate is $5.007 trillion. For the real growth rate in 2012 and 2013 estimation is 2% For the per capita PPP in 2012 is $36,300 and 2013 estimation is $37,100. Besides that, Malaysia have many different economy categories such as unemployment rate, population below poverty line. For the unemployment rate in 2012 estimation is 4.4% and in 2013 estimation is 4.1%. For the population below poverty line in 2012 and 2013 estimation is at 16%. Furthermore, for the budget consists of 2 categories which are revenues and expenditures. For the revenues in 2012 and 2013 estimation is $1.739 trillion. For the expenditures in 2012 and 2013 estimation is $2.149 trillion. In conjunction with the budget expenditures there is taxes which applies on the expenditures as well. For the taxes and other revenues is 34.7% GDP and for the budget deficit is -8.2% of GDP. For the consumer prices will have inflation rate as well. In 2012 estimation is 0% and in 2013 estimation is 0.2%. Lastly is the exports and imports for the country in Malaysia. For the exports in 2012 estimation is $776.6 billion and in 2013 estimation is $697.0 billion. For the imports in 2012 estimation is $830.1 billion and in 2013 estimation is $766.6 billion. The next category is people and society. There is 5 categories which is population, human development index, human poverty index, poverty rates and population growth rates. For the population in Malaysia for 2012 and 2013 estimation is 127,103,388 people. For the human development index in 2012 and 2013 estimation is 0.912. For the poverty rates in 2012 and 2013 estimation is 11.1%. Finally, for the population growth rates in 2012 and 2013 estimation 15.7%. Finally, for the population growth rates in 2012 and 2013 estimation is 0.13%. United States United States have 4 types of GDP which is purchasing power parity, official exchange rate, real growth rate and per capita PPP. For purchasing power parity in 2012 estimation is $16.47 trillion and in 2013 estimation is $16.72 trillion. In 2012 and 2013 estimation for the official exchange rate is $16.72 trillion. For the real growth rate in 2012 is 2.8% and 2013 estimation is 1.6%. For the per capita PPP in 2012 is $52,400 and 2013 estimation is $52,800. Besides that, Malaysia have many different economy categories such as unemployment rate, population below poverty line. For the unemployment rate in 2012 estimation is 8.1% and in 2013 estimation is 7.3%. For the population below poverty line in 2012 and 2013 estimation is at 15.1%. Furthermore, for the budget consists of 2 categories which are revenues and expenditures. For the revenues in 2012 and 2013 estimation is $2.849 trillion. For the expenditures in 2012 and 2013 estimation is $3.517 trillion. In conjunction with the budget expenditures there is taxes which applies on the expenditures as well. For the taxes and other revenues is 17% GDP and for the budget deficit is -4% of GDP. For the consumer prices will have inflation rate as well. In 2012 estimation is 2.1% and in 2013 estimation is 1.5%. Lastly is the exports and imports for the country in Malaysia. For the exports in 2012 estimation is $1.561 trillion and in 2013 estimation is $1.575 trillion. For the imports in 2012 estimation is $2.303 trillion and in 2013 estimation is $2.273 trillion. The next category is people and society. There is 5 categories which is population, human development index, human poverty index, poverty rates and population growth rates. For the population in Malaysia for 2012 and 2013 estimation is 127,103,388 people. For the human development index in 2012 and 2013 estimation is 0.912. For the poverty rates in 2012 and 2013 estimation is 11.1%. Finally, for the population growth rates in 2012 and 2013 estimation 15.7%. Finally, for the population growth rates in 2012 and 2013 estimation is 0.13%. 5 Ways To Improve Your Country’s Economic Development And Standard Of Living 1. Wage your levies: An efficient tax collection and management system is important for a country’s economy growth. Besides exports, the majority of revenue is from taxation, without taxation, the government cannot invest in infrastructure, social programs or compensate government officials. Sales taxes, income taxes, payroll taxes and wealth taxes are made by taxpayer into the economy to improve the collective standard of living. This includes the benefit from getting better roads, schools, hospitals and a welfare system. 2. Animate within your means: By saving money and keeping your debt lower than your disposable income, you will be less vulnerable recession. For example, if your credit cards, mortgage loans, the outstanding balance of auto loans and student loans is more than your savings, investments and property combined, then the problem will come to you. It means you may have a dissatisfied conditions, as like a sudden drop in unexpectedly financial obligations. 3. Acquire valuable teaching: The education level is highly associated to the economic growth. In other words, the more skilled of the population is (composed for example of engineers, physicists, agricultural biologists, construction workers, etc), the more productive, competitive and autonomous that a country can be. For example, with the right expertise, food security can be guaranteed by increasing agricultural production; a plenty of goods can be manufactured and exported; and natural resources can safely use and local change. So by getting a professional education that is in demand, you will help your country to get productivity and a strategic advantage. 4. Devour properties and facilities created locally: By selecting to buy a five-dollar t-shirt made in your country instead of the exact same t-shirt selling for one dollar but made abroad, you just made a major positive impact: the money stayed in the local economy, domestic jobs were compensated and small businesses remain open. 5. Chosen administration bureaucrats in errand of financial development: All of the advice above cannot be effective without leaders who fight for corruption, foster a fair trade and business agreements, promote financial transparency, support for protectionist labor laws, avoid excessive public and consumer debt, engage in a prudent monetary and fiscal policy development, boost job creation, ease access to important sectors of education and healthcare, subsidize vital industries and help small businesses. 2. What is ‘Dumping’ and why do countries implement ‘Anti-dumping’ legislation? Do you think such legislations are required in today’s free trade world market? Discuss with supporting data and relevant duties What is dumping? Dumping happens when the export price of the goods in Malaysia is lower than the usual price of the similar or alike artefact in the inland market in the nation of export or basis. In other words, dumping is an global value discernment which the corporation custodies more in its inland marketplace than in the export marketplace. What is export price? Export price is actually the value that salaried or owed for the topic merchandise (supposedly vended at dumping values in Malaysia for overseas products) . In cases the export price may be built on the topic merchandise are first resold to an self-governing purchaser on basis of price. What is subject merchandise ? Subject merchandise means the lesson or kind of merchandise imported or vended imported into Malaysia that is the topic of any countervailing or anti-dumping responsibility act under Act 504. What is like product? Like product means a product which is alike or like in all compliments to the topic merchandise, and comprise other artefact which comprise bodily, technical or biochemical physiognomies, applications or uses that nearly alike to those the topic merchandise. What is normal value? Normal value is the value salaried in the normal course of interchange in the inland marketplace of the nation of export. Auctions used to verify the usual price which must be lucrative and unaffected by any association between the purchaser and vender. Nations comply ‘anti-dumping’ lawmaking because to authorizing the Examining Specialist to take corrective events against unfair interchange by overseas builders/exporters and to deliver a outline for examining accusations of damage caused by dumped or funded imports. I think such legislations are required in today’s free trade world market due to: Anti-dumping actions (Legal issues) If a corporation exports a artefact at a worth that is fewer than the worth it usually custodies in its own home-based marketplace, or vended properties at a worth which does not encounter its filled cost of manufacture, it is called as dumping the artefact. It is a sub-section of numerous forms of worth discernment and is registered as third gradation worth discernment. Many administrations take act against dumping to defend inland business and the WTO contract concentration is on how administrations can or cannot respond to dumping. It disciplines anti-dumping contract. The administration must compute the boundary of dumping (how much lower of the export worth compared to the exporter’s home-based marketplace worth), and show that the injured of dumping. References: Fatima, R. (2014). MITI. Retrieved 12 May 2014, from http://www.miti.gov.my/cms/content.jsp?id=com.tms.cms.section.Section_e2f9c09d-c0a8156f-282d282d-9947bc72 Adkins, T., Alvin, M. (2009). Dumping Definition | Investopedia. Retrieved 12 May 2014, from http://www.investopedia.com/terms/d/dumping.asp Azhar, A., Reserve, T. (2014). Govt imposes anti-dumping duty on FCB from Thailand. Free Malaysia Today. Retrieved 12 May 2014, from http://www.freemalaysiatoday.com/category/business/2013/11/29/govt-imposes-anti-dumping-duty-on-fcb-from-thailand/ Gwet, M., Gwet, M. (2013). 5 things you can do to help your country’s economy BobbyFinance. BobbyFinance. Retrieved 13 May 2014, from http://bobbyfinance.com/2013/05/24/5-things-you-can-do-to-help-your-countrys-economy/# Britt S.L. (2014). The World Factbook. Retrieved 2 June 2014, from https://www.cia.gov/library/publications/the-world-factbook/geos/my.html

Free Essays - Individual vs. Society in Catcher in the Rye :: Catcher Rye Essays

Individual vs. Society in Catcher in the Rye In the novel Catcher in the Rye, many differences exist within the plot and between the characters. This makes the book so interesting. But what interest me, is that the main character, Holden, is the most distinctive example of a difference. Usually, societies approve of a level of uniqueness. But when individuality turns into clear differences of attitude and opinion, conflict starts to arise. Because Holden's morals and beliefs are those different from the society in which he lives in, he can't function in that particular society. Throughout the book, certain values of Holden start to show through. He speaks a lot about how he dislikes "phonies" and tries to separate himself from them. Every time Holden tries to run away from these "phonies," it starts to give you an idea about how he values honesty and his reaction towards people who don't have this particular value. In chapter seventeen, Holden tries to rationalize himself being kicked out of school by saying he wants to accomplish something different and not just be a phony. "It's full of phonies, and all you do is study so that you can learn enough to be smart enough to be able to buy a goddam Cadillac some day, and you have to keep making believe you give a damn if the football team loses, and all you do is talk about girls and liquor and sex all day, and everybody sticks together in these dirty little goddam cliques (Salinger 131)." In life, and as his days go by, he will realize that many people in society and people who run it, are indeed n ot genuine. The reality angers Holden and he fantasizes about running away, escaping from society, and living in a cabin away from everybody. This is a far-fetched idea that is hardly even an option for him. He decides that if he can't fit in a society where he isn't wanted, then he won't be a part of it. This thought would have never come across Holden's mind if he was like everybody else, but he isn't. Holden obviously can't deal with the environment around him and one day may lash out to the elements of life that aren't in agreement with him. Free Essays - Individual vs. Society in Catcher in the Rye :: Catcher Rye Essays Individual vs. Society in Catcher in the Rye In the novel Catcher in the Rye, many differences exist within the plot and between the characters. This makes the book so interesting. But what interest me, is that the main character, Holden, is the most distinctive example of a difference. Usually, societies approve of a level of uniqueness. But when individuality turns into clear differences of attitude and opinion, conflict starts to arise. Because Holden's morals and beliefs are those different from the society in which he lives in, he can't function in that particular society. Throughout the book, certain values of Holden start to show through. He speaks a lot about how he dislikes "phonies" and tries to separate himself from them. Every time Holden tries to run away from these "phonies," it starts to give you an idea about how he values honesty and his reaction towards people who don't have this particular value. In chapter seventeen, Holden tries to rationalize himself being kicked out of school by saying he wants to accomplish something different and not just be a phony. "It's full of phonies, and all you do is study so that you can learn enough to be smart enough to be able to buy a goddam Cadillac some day, and you have to keep making believe you give a damn if the football team loses, and all you do is talk about girls and liquor and sex all day, and everybody sticks together in these dirty little goddam cliques (Salinger 131)." In life, and as his days go by, he will realize that many people in society and people who run it, are indeed n ot genuine. The reality angers Holden and he fantasizes about running away, escaping from society, and living in a cabin away from everybody. This is a far-fetched idea that is hardly even an option for him. He decides that if he can't fit in a society where he isn't wanted, then he won't be a part of it. This thought would have never come across Holden's mind if he was like everybody else, but he isn't. Holden obviously can't deal with the environment around him and one day may lash out to the elements of life that aren't in agreement with him.